It includes portions of Serengeti National Park and Ngorongoro Conservation Area, which are designated World Heritage Sites and biosphere reserves for their outstanding wildlife and landscapes.

A belt of miombo woodland, Serengeti volcanic grasslands, and East African montane forests separate the northern and southern blocks.

[1] The predominant vegetation types are open grassland, savanna, and open-canopy woodland, with species of Acacia, Commiphora, and Crotalaria as the dominant trees, and Themeda triandra, Setaria incrassata, Panicum coloratum, Aristida adscensionis, Andropogon spp., and Eragrostis spp.

[1] The ecoregion is home to globally outstanding populations of large mammals, including great herds of wildebeest (Connochaetes taurinus), plains zebra (Equus burchelli), and Thomson's gazelles (Gazella thomsoni).

Ruaha National Park (14506.69 km2),[7] Tanzania's largest, and adjacent game reserves and wildlife conservation areas preserve a broad swath in the southwest.