[3] Southern Airways Express, commonly referred to as 'Southern', acts as a local service airline for dozens of cities across all U.S. time zones.

Southern's initial funding was secured by a group of unknown investors, many of whom are believed to be connected to the University of Mississippi, the alma mater of Little and co-founder Keith Sisson.

In March 2014, Southern made its first acquisition, acquiring Executive Express and its FAA charter certificate, retaining all of its employees in the process.

(Executive Express Aviation was later sold to FLOAT Shuttle in 2019 for an undisclosed sum, when all Southern-operated flights were consolidated to its primary certificate.)

Sun Air flew multiple EAS routes in the mid-Atlantic region, immediately strengthening Southern's presence in the federal program.

The Southern Airways Express Saab 340s started operating in Hawai'i in July 2022, with service linking Honolulu to Lana'i and Moloka'i.

[9] Shortly after the COVID-19 pandemic caused a mandatory inter-island quarantine in Hawaii, Southern/Mokulele announced its fourth acquisition: Honolulu-based Makani Kai Air, a division of Schuman Aviation.

[12] On March 30, 2023, it was announced that the Marianas Southern Airways division of the airline was withdrawing from the CNMI, citing "unwillingness of Governor Arnold Palacios to honor the contract signed by the previous administration".