Southern Cross opened as the original terminus of Eastern Goldfields Railway on 1 July 1894.

[3] When a new standard gauge Eastern Goldfields Railway was built, it bypassed the town.

To the west of the station lies a yard to serve a grain silo.

[4] The Prospector service, which runs each way between East Perth and Kalgoorlie once or twice each day, stops at Southern Cross.

[5] The Indian Pacific also passes here, running once or twice a week (depending on the time of year) each way between East Perth and Sydney Central, but does not stop at the station.