Southern High School is a public secondary school located at 1 Jose Perez Leon Guerrero Drive in the village of Santa Rita, in the United States territory of Guam.

[2] Southern High serves the villages of Santa Rita, Agat, Asan-Maina, Inarajan, Merizo, Piti, Talofofo, Umatac, and Yona.

[3] In January of 2023, the school received a "D" grade for safety and public health from the Guam Department of Public Health due to various infractions, including inaccessible drinking fountains.

[3] Students may participate in interscholastic athletics if they are under the age of 19 on September 1 of the applicable school year.

[1] School athletics include: coeducational: American football, Cheerleading, Paddling, Rugby, and Wrestling; male only: Baseball; and female only: Softball.