[3] Southern Illinois University Edwardsville (SIUE) is the St. Louis Metro East campus of the SIU system.
The main campus in Edwardsville is situated on 2,660 acres (1,080 ha) of scenic woodland and lakes with bicycle and walking paths throughout.
[5] The Southern Illinois University School of Medicine (SIU-SOM) is a part of SIUC that operates its first-year program in Carbondale and the final three years in Springfield.
[6] The Simmons Cancer Institute is a medical education, biomedical research, patient care, and community service facility in Springfield operated by the SIU-SOM.
The Southern Illinois University School of Dental Medicine (SIU-SDM or SDM) is a part of SIUE and is located in Alton on the campus of the former Shurtleff College.
[10] Southern Illinois University Edwardsville School of Nursing not only has academic programs on the Edwardsville campus, but it operates a cooperative program with SIUC in Carbondale, and it has a small campus in Springfield which offers graduate level courses nearby the SIU School of Medicine.
[11] SIU Carbondale operates aviation programs at the Transportation Education Center, located at the Southern Illinois Airport, about 15 minutes from the main campus.
Programs include Illinois workNet, providing adults and youth with disabilities the resources to help them reach educational and employment goals; the Website Development Project, working with the Illinois Department of Employment Security to redesign the agency's website to provide improved access to the department's services by individuals, businesses, and the departmental staff; Illinois Pathways, a STEM education improvement program supported by six other State of Illinois agencies; and the SIUC Workforce Education and Development program's Off Campus Undergraduate Program on the campus of Lincoln Land Community College, which provides a one-year degree completion program for students who have already received an Associate Arts or Associate of Science degrees from Illinois community colleges.