The Southern Miss Lady Eagles women's basketball team represents the University of Southern Mississippi in women's basketball.

The school competes in the Sun Belt Conference in Division I of the National Collegiate Athletic Association (NCAA).

The Lady Eagles play home basketball games at Reed Green Coliseum in Hattiesburg, Mississippi.

[2] As of the end of the 2022–23 season, the Lady Eagles have a 801–598 all-time record.

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