Southern Railway Depot, also known as Ninety Six Depot, is a historic train station located at Ninety Six, Greenwood County, South Carolina.

It was built in 1915 by the Southern Railway, and is a combination passenger and freight depot.

It is a one-story, rectangular brick building with a flared hipped roof, bay window, station master's room, and segregated waiting rooms.

[2][3] It was listed on the National Register of Historic Places in 2011.

This article about a property in Greenwood County, South Carolina on the National Register of Historic Places is a stub.