Southern Railway Depot, also known as the North Wilkesboro Depot, is a historic train station located near North Wilkesboro, Wilkes County, North Carolina.

It was built in 1914 by the Southern Railway, and is a long, one-story brick building with American Craftsman style design elements.

It measures 36 feet wide and 240 feet long and has a low hipped roof with overhanging eaves.

[2] It was listed on the National Register of Historic Places in 2004.

[1] This article about a property in Wilkes County, North Carolina on the National Register of Historic Places is a stub.