Southern Seminary Main Building, originally known as the Hotel Buena Vista and now Main Hall of Southern Virginia University, is a historic hotel building located at Buena Vista, Virginia.

It was built in 1890, and is a 3 1/2-story, brick and frame building in an eclectic combination of Queen Anne and French Renaissance style architecture.

It features a steep slate covered gable roof, round towers with conical and domical roofs, three-level wooden galleries, and Palladian windows.

[3] It was listed on the National Register of Historic Places in 1972.

This article about a property in Buena Vista, Virginia on the National Register of Historic Places is a stub.