Through various expansions during its history, it has grown into a university-affiliated teaching and research facility, specifically offering advanced cardiac, cancer, and thoracic care.

[citation needed] In 1927, the new hospital building was completed by the architects Craig and Madill.

[1] The hospital is connected to the Southlake Regional Cancer Centre to its west and to a Medical Arts building by an arch bridge to its north, occupied principally by the University of Toronto's Family Medicine Teaching Unit and other health services.

The Stronach Regional Cancer Centre is partnered with Princess Margaret Hospital.

the hospital is averaging more than 6000 medical training days per year, which is approximately triple its numbers in 2008.