Southmoreland High School is located in East Huntingdon Township, Westmoreland County, Pennsylvania, 40 miles southeast of downtown Pittsburgh.

Dual enrollment courses are available in the following subjects: English Literature, American Politics, Physics 1, and Calculus 1.

In 1805, the first schoolhouse in East Huntingdon township was built adjacent from Gaut’s Dairy Farm in rural Scottdale, near Alverton.

[5] The site of the former school was converted to a parking lot for Russ Grimm Field, dubbed Scotland Yard.

Southmoreland linebacker Russ Grimm went on to play professional football for the Washington Redskins where he would become a three time Super Bowl champion and be inducted into the Pennsylvania Sports Hall of Fame in 2023.

During a 41–0 shutout victory against Derry Area High School, running back Lily Wasmund scored a touchdown in the final minutes of the game.

This touchdown was the first to be scored by a female player in the 114-year history of the Western Pennsylvania Interscholastic Athletic League (WPIAL)[13] On August 28, 2018, after more heavy rain in the area, the presence of mildew and mold were discovered in two of the school's classrooms.

[19] The school's marching band, soccer team, and cheerleading squad also utilize Cardiac Hill as a practice field.

[20] In order to reach the school's athletic track from the softball field, the hill requires visitors to drive a quarter of a mile uphill on Scottie Pride Way.

Frederick had served as the high school Scotties' assistant football coach for four years prior to his promotion, helping lead the team to a nearly undefeated season and playoff appearance at the conclusion of the 2019 season, breaking a 40 year playoff drought, the longest in the Western Pennsylvania Interscholastic Athletic League.

On May 19, 2010, a janitor at Southmoreland had been doing routine cleaning of the school's stairwells when they discovered the presence of blood what was believed to be a human fetus.

In addition to this, Fike reportedly presented a handwritten note addressed to the entirety of the board that outlined her refusal to follow the district's mask policy.

[35] During the April 15, 2021 school board meeting, Fike thrusted Southmoreland into the national spotlight when she wore a paper bag over her head in protest of the district's mask policies.