The Southwestern Lacrosse Conference (SLC) is a lacrosse-only athletic conference affiliated with the Men's Collegiate Lacrosse Association (MCLA).

The SLC is formed from original members of the Western Collegiate Lacrosse League which was the largest MCLA conference in the nation at the time.

Because of rapid growth and teams spread out over a very large area, the members decided it was best to start a new conference and the SLC was born August 2008 with the blessing of the WCLL and MCLA.

The teams are members of the MCLA and the Division I and Division II conference tournament winners receive an automatic bid to the MCLA National Tournament.

[1] The 2023 season saw the introduction of a Division III component to the conference, comprising community colleges and junior colleges.