She was part of the Northern Fleet until her loss in 1943.

Operating against Axis shipping in Norwegian waters, K-22 focused on gunnery attacks with her artillery.

On 9 April 1942 she discovered the damaged submarine ShCh-421, which had been disabled by a mine.

K-23 rescued ShCh-421's crew and then scuttled the disabled submarine with a torpedo.

On 7 February 1943, K-22 was sunk with all hands by an enemy mine.