[1] It transported three members of the Expedition 53 crew to the International Space Station.

The crew consisted of a Russian commander, and two American flight engineers.

[3] It returned to Earth on 28 February 2018 after 168 days in orbit.

[2] Due to a decision to cut down the number of participating Russian astronauts in 2017, changes were made in crew assignments to the ISS.

[5] Originally set to be on Soyuz MS-04, Alexander Misurkin and Mark T. Vande Hei have been assigned to Soyuz MS-06 instead.