The launch was previously planned for 30 March 2022, but in the provisional flight manifest prepared by Roscosmos by the end of Summer 2020, the launch of Soyuz MS-21 was advanced to 18 March 2022.

[4] On 29 September 2022, after 6 months and 11 days, the mission completed successfully as planned with a landing on the Kazakh Steppe in Kazakhstan.

[6] Although NASA had not decided whether or not they would purchase a seat on the flight, NASA astronaut Loral O'Hara was preparing to replace Sergey Korsakov if the agency decided to buy a seat.

[7] Later, NASA decided not to acquire a seat on the Soyuz MS-21 launching in March 2022, deferring a NASA Roscosmos seat swap for Soyuz MS-22 and SpaceX Crew-5.

[9] International commentators saw in these colours the national colours of Ukraine and interpreted the personal choice of suits by the cosmonauts as a sign of their sympathy for Ukraine in the light of the parallel ongoing 2022 Russian invasion of Ukraine, which strained also space cooperation such as the ISS program after international sanctions on Russia.