The Soyuz TMA-16 (Russian: Союз TMA-16) was a crewed flight to and from the International Space Station (ISS).

It transported two members of the Expedition 21 crew[1] and a Canadian entrepreneur from the Baikonur Cosmodrome in Kazakhstan to the ISS.

On January 21, 2010, cosmonaut Suraev and Expedition 22 Commander Jeffrey Williams relocated the spacecraft to the zenith-facing port of the Poisk module.

[7] The Soyuz TMA-16 spacecraft undocked from the aft end of the Zvezda service module at 5:03 a.m. EST and backed away to a distance of about 100 feet from the space station.

Re-docking occurred at 5:24 a.m. EST after Suraev fired the Soyuz maneuvering thrusters to fly halfway around the orbiting space station and line up with the Poisk module.