[5] NASA has contracted for the CRS-6 mission from SpaceX and therefore determines the primary payload, date/time of launch, and orbital parameters for the Dragon space capsule.

SpaceX CRS-6 included science payloads for studying new ways to possibly counteract the microgravity-induced cell damage seen during spaceflight, the effects of microgravity on the most common cells in bones, gather new insight that could lead to treatments for osteoporosis and muscle wasting conditions, continue studies into astronaut vision changes and test a new material that could one day be used as a synthetic muscle for robotics explorers of the future.

The unmanned launch vehicle technically landed on the floating platform, however it came down with too much lateral velocity, tipped over, and was destroyed.

[11] Elon Musk later explained that the bipropellant valve was stuck, and therefore the control system could not react rapidly enough for a successful landing.

[9][13] On 15 April 2015, SpaceX released a video of the terminal phase of the descent, the landing, the tip over, and a small deflagration as the stage broke up on the deck of the ASDS.