The mission was successfully launched on 5 October 2022 with the aim of transporting four crew members to the International Space Station (ISS).

This mission marked a significant milestone as it was the first time a Russian cosmonaut, Anna Kikina, flew aboard a Crew Dragon spacecraft.

This system ensures that each crew rotation mission includes at least one NASA astronaut and one Roscosmos cosmonaut, allowing both countries to maintain a presence on the International Space Station (ISS) and the ability to sustain their respective systems in case one of the vehicles, either Soyuz or commercial crew, is grounded for an extended period.

The International Space Station mission management team decided to move NASA astronaut Francisco Rubio's Soyuz seat liner from the Soyuz MS-22 spacecraft to Dragon Endurance to provide lifeboat capabilities in the event Rubio needed to return to Earth because of an emergency evacuation from the space station.

The change allowed for increased crew protection by reducing the heat load inside the MS-22 spacecraft for cosmonauts Sergey Prokopyev and Dmitry Petelin in the event of an emergency return to Earth.