His enemies included Zorak, Brak and his brother Sisto, the Creature King,[6] the Black Widow/Spider Woman, Moltar, and Metallus.

The cartoon also features a woolly mammoth named Tusko whom Ugh would enlist in certain episodes to help him, Dino Boy, and Bronty out.

[9] Many of the scripts for Space Ghost and future action adventure shows would be written by Joe Ruby and Ken Spears.

[9] Brainstorming sessions for the series would typically involve Silverman and William Hanna throwing out character descriptions and concepts while Joseph Barbera and Alex Toth translating them as rough sketches and doodles.

Additionally, they feature cameos from other characters (The Herculoids, Moby Dick, the Mighty Mightor, and Shazzan) that would appear in their own Hanna-Barbera series broadcasts on CBS the following (1967–68) season.

In 2016, Space Ghost and his allies and Dino Boy played a major role in the DC Comics series Future Quest, that also featured characters from various animated series produced by Hanna-Barbera such as Jonny Quest, The Herculoids, Birdman and the Galaxy Trio, Frankenstein Jr. and The Impossibles and Moby Dick and Mighty Mightor.

[18] In 1994, nearly three decades after the finale of the original series, Mike Lazzo pitched the idea of an adult animated parody talk show using the Space Ghost character to Cartoon Network.

[19] The series was revived on May 7, 2001, and was moved to the new Adult Swim late-night programming block on September 2 of that year, where new episodes premiered until April 12, 2004.

"[20] Space Ghost proved considerably popular on its initial run and is credited with spurring a wave of similar superhero themed action-adventure shows across all three major networks from 1967 to 1969.