This building, with its pseudo-mansard roof and brick arches and no obvious bold signage like most other station entrances, is located at the easterly end of the Bloor line platforms.

There is a secondary entrance building directly opposite, on the west side of Spadina Road, which is only accessible to those with Presto cards.

At the street level, there are three large cedar wood carvings called K'san Village House Posts depicting an owl, a wolf and a hawk.

The main entrance to the Yonge–University line part of the station is concealed inside a house at 85 Spadina Road, which was built in 1899 and listed as a heritage property by the City of Toronto in 1974.

[7][8] Opposite the house, on the west side of Spadina Road at Kendal Avenue, there is an uncovered stairwell entrance to the station mezzanine.

This building includes two large artworks: Morning Glory by Louis de Niverville, a surreal enamel mural sited on the ground level by the stairwell; and Barren Ground Caribou by Joyce Wieland, a huge quilt[9] featuring caribou in a tundra landscape, located near the unmanned turnstile on the concourse level below.

In 2022, the Toronto Transit Commission proposed constructing elevators for the side platforms of Spadina station on Line 1; they will connect to the street level concourse.

Destinations and nearby points of interest include the Spadina Road Branch of the Toronto Public Library, Native Canadian Centre of Toronto,[13] Miles Nadal Jewish Community Centre,[14] Bloor Street United Church, and Trinity-St. Paul's United Church.