Spadina was a Canadian electoral district that was represented in the House of Commons of Canada from 1935 to 1988.

It covered a portion of the western-central Toronto, Ontario.

Its name comes from the Spadina Avenue, which runs through the heart of the riding.

As this northern portion of became more populated it was split off into other ridings.

In 1987, due to the relative decrease in the population of downtown Toronto compared to other areas, it was merged with Trinity to form Trinity—Spadina.