[3] They are sold in tomato sauce and with additions including meatballs, pieces of processed meat resembling hot dog slices, beef-filled ravioli, and calcium-fortified spaghetti.

[3][7] SpaghettiOs were introduced nationally without test marketing[7] and with television advertising using the tag line "the neat round spaghetti you can eat with a spoon" and the jingle "Uh-Oh!

[5] Campbell's launched Spicy Original SpaghettiOs featuring Frank's RedHot in 2023, designed to appeal to millennials, calling it a "hot, more mature twist on a classic offering that our adult consumers grew up enjoying" according to one company executive.

The post also quickly spawned parodies, as other users such as comedian Patton Oswalt edited the cartoon SpaghettiO into photos of other national tragedies such as the assassination of John F. Kennedy, 9/11, the Hindenburg disaster, the Space Shuttle Challenger explosion, and the sinking of the Titanic.

[13][14] Actress and comedian Natasha Leggero faced criticism for remarks regarding the tweet during NBC's New Year's Eve with Carson Daly later that month, where she quipped that "it sucks that the only survivors of Pearl Harbor are being mocked by the only food they can still chew."