It was founded as a cell of Croyland Abbey, in 1052, by Leofric, Earl of Mercia and his wife, Godiva, Countess of Leicester.
Ælfgār, Earl of Mercia and the monks were confirmed in their property in 1074, after the Norman Conquest of England.
After 1071 one monk only remained in Spalding, so the house was refounded in 1074 as a dependent priory of St Nicholas's Abbey, Angers.
Six human skeletons found during building work in Bridge Street are presumed to indicate the site of the Priory burial ground.
[2] The lands of the house passed to the family of Sir Richard Ogle of Pinchbeck, and were included in the English jointure of Anne of Denmark in 1603.