From 1599 to 1603, Baltasar de Zúñiga was ambassador of Philip III of Spain to the court of Isabella Clara Eugenia and Albert VII, Archduke of Austria at the Palace of Coudenberg (today Brussels Park).

On 28 October 1965, José Núñez Iglesias was replaced by Alberto Ullastres Calvo as President of the Spanish mission to the European Common Market.

The ambassador is appointed to the Council of Ministers, they direct the work of all the offices that depend on the embassy, based in Brussels.

Likewise, it informs the Spanish Government about the evolution of events in Belgium, negotiates on behalf of Spain, can sign or ratify agreements, observes the development of bilateral relations in all fields and ensures the protection of Spanish interests and its citizens in Belgium.

The current ambassador is Alberto Antón Cortés, who was appointed by Pedro Sánchez's government on 27 September 2022.