Spanish River Boulevard is a short east–west highway in Boca Raton, Palm Beach County, Florida.

The western terminus of Spanish River Boulevard is at its intersection with Military Trail (CR 809), in the Lynn University area of Boca Raton, Florida.

The highway narrows briefly to three lanes (two westbound and one eastbound) as it crosses over Interstate 95 (I-95) and the Tri-Rail tracks.

From there, the highway passes along the northern edge of Florida Atlantic University and the Boca Raton campus of Palm Beach State College.

At the intersection with Northwest 4th Avenue, Spanish River Boulevard turns to the southeast, passing several local residences.