Don Antonio de Ulloa was a Velasco-class unprotected cruiser of the Spanish Navy that fought in the Battle of Manila Bay during the Spanish–American War.

Don Antonio de Ulloa was built at La Carraca shipyard, Cadiz, Spain.

[3] Transiting the Mediterranean Sea, Suez Canal, and Indian Ocean, the division encountered rough weather during its journey only in the Gulf of Lyons.

She was in this condition when the Spanish–American War broke out in April 1898, and was anchored as part of the squadron of Rear Admiral Patricio Montojo y Pasarón in Manila Bay.

During Dewey's first pass, Don Antonio de Ulloa took a few hits, the most destructive being a large shell that burst on the upper deck and killed nine men—among them her commanding officer—and wounded another ten, leaving almost no one aboard to man her remaining guns.

There was also no one able to strike her colors; when Dewey's squadron reversed course and made a second firing pass, they assumed the still-flying battle ensign meant that Don Antonio de Ulloa was still in action.

After the battle, a boarding party from gunboat USS Petrel went aboard and set the wreck of Don Antonio de Ulloa on fire.