Officially named Santísima Trinidad y Nuestra Señora del Buen Fin, and familiarly known as The Mighty (Spanish: El Poderoso), she is not to be confused with the ship-of-the-line the Nuestra Señora de la Santísima Trinidad, the largest warship in the world when launched in 1759.

Armed with 60 guns, her keel was laid in Bagatao Island shipyard (Real Astillero) Sorsogon in 1751 with a carrying capacity of 2,000 tons.

[1]: 213  Orders came from the Governor-General of the Philippines Don Francisco José de Ovando, 1st Marquis of Brindisi.

In 1755, the Santísima Trinidad, steered by French pilot Antoine Lemaire de Boucourt, made a bad voyage from Manila to Acapulco which lasted 221 days and is said to be the third longest in the history of the line; it started on 23d of July, 1755, with 435 persons on board, of whom 74 died on the way, by tabardillo, a kind of typhus, and/or by lack of water (rainfall).

The voyage ended in Acapulco, after a long stop in San José del Cabo, on 27 February 1756.