Over the course of her career Galerna had taken part in a number of international and NATO exercises, including Sorbet Royal, Dogfish, Linked Seas, Dragon Hammer, Noble Marlin, TAPÓN, ALFEX, and MINEX.

On 26 May 2016 Galerna returned to Cartagena from a deployment with the anti-terrorist Operation Active Endeavour in the Mediterranean.

During the deployment Galerna spent a month and a half monitoring possible illegal and terrorist activities.

However, due to delays in the successor S-80-class program, they have undergone numerous repairs.

Galerna was scheduled for another large overhaul in the summer of 2017, the fifth over her career, to extend her service life until the delivery of the next generation of submarines.