The brewery expanded greatly during the following 125 years, until it belonged to the family Starnberger for exactly a century from 1522 to 1622.

In 1874, Johann Carl and Anton Sedlmayr acquired ownership of the brewery from their father, Gabriel.

In 1922, the Spatenbräu and Franziskaner-Leist-Bräu breweries, both owned by the Sedlmayr family, were joined into the company Gabriel-und-Joseph-Sedlmayr-Spaten-Franziskaner-Leistbräu.

The Spaten brewery suffered severe damage during the Allied bombing of Munich from 1943 to 1945, and because of this, export of beer to other countries in Europe and overseas was only again possible in 1950.

Since then, the premises of the Spatenbräu brewery have hosted a visitor museum, and no brewing of beer takes place there anymore.

During the new year between 2009 and 2010, it became known that the AB-InBev concern was taking closing down the Spatenbräu and Löwenbräu breweries into consideration.

In October 2010, the brewery announced that it had postponed the plans to move into new premises inside the city into the future.

The invention of the first steadily working chiller by Carl von Linde in 1873 was supported by the brewery.

Spaten has brewed a variety of beer including Lager, Oktoberfestbier, Optimator, Munchner Hell, Pils, Light, Alkoholfrie, Champagner-Weiße, Dunkel, Bock, Gold, Special Dark and MaiBock.