[2] The park is a designated protected area that is intended for the conservation and research on caribou, grizzly bears, fish, and other wildlife species populations.

[7] After the late 19th century, individuals like prospectors, hunters, and trappers explored the area for resources,[5] and the Hyland Brothers established a post by the Spatsizi River.

[5] In 2001, the provincial park added more parkland following the Cassiar Iskut Stikine Land and Resource Management Plan (CIS LRMP), altering the Gladys Lake Ecological Reserve Boundary.

[13] Caribou in the area tend to winter along the Stikine River, and in general were found in higher concentrations in the northern portion of the park all year.

[15] Gladys Lake Ecological Reserve was created simultaneously and lies within the park, with the express purpose of studying Stone sheep and mountain goats,[16] though in the modern day the scope of research in the area has expanded, most notably to include caribou and moose.

[3] For the Spatsizi Plateau Wilderness Provincial Park, the cultural heritage role assigned to the area has protected village sites of the Caribou Hide and Metsantan First Nations.

[3] In Spatsizi Plateau Wilderness Provincial Park, the Tahltan First Nation has used the area in the past for many generations, holding cultural significance to them as the land contains a rich history because of how the traditional ceremonies and practices conducted are essential for identity.

[2] The Tahltan First Nation has extensively used the land, emphasizing inter-community trade with nearby Indigenous communities like the Tlingit, Kaska, and Sekani people and Aboriginal subsistence through hunting and fishing.

Visitors can enjoy activities like hiking, wildlife viewing, canoeing, fishing, camping, photography, stargazing, and guided nature interpretation.

The park's pristine environment and stunning landscapes provide a unique outdoor experience, and responsible tourism practices are encouraged to protect its natural beauty.