U.S. Route 76 Business was established in 1958 as a renumbering of mainline US 76 through downtown Seneca, via North 1st Street.

It was established in 1979 on the former route of mainline US 76 through downtown Laurens on Main Street after the highway was relocated to a bypass.

It exists in three different segments and is located in the west-central part of Richland County and entirely within the city limits of Columbia in the U.S. state of South Carolina.

The western segment of US 76 Conn. is a 2.9 mi-long (4.7 km) highway that begins at an intersection with US 21/US 176/US 321 (Blossom Street/Huger Street).

It passes Greek Village, the fraternities and sororities of the University of South Carolina (USC).

[9][10] The central segment of US 76 Conn. is a 0.4 mi-long (640 m) highway that begins at an intersection with SC 16 (Beltline Boulevard) southwest of Brennen Elementary School.

It travels east-southeast on Rosewood Drive and passes the Beltline Campus of Midlands Technical College.

The highway curves to the east-northeast and meets its eastern terminus, an intersection with SC 760 (Fort Jackson Boulevard).

is a 5.910 mi (9.511 km) business route that is entirely within the city limits of Sumter.

A roundabout intersection with US 701 Business surrounds the Columbus County Courthouse which is listed on the National Register of Historic Places.

NC 410 continues south along Brown Street toward downtown Chadbourn and Tabor City.

After intersecting Elm Street, the road narrows to a two-lane facility while following Strawberry Avenue in northern Chadbourn.

US 76 Business provides access to Southeastern Community College, located east of Chadbourn.

The intersection marks the eastern end of the NC 130 concurrency, as the highway follows US 701 to the south.

US 76 Business continues east along Jefferson Street, exiting the town limits.

Shortly before its eastern terminus, the highway widens to a four-lane road and intersects NC 214.

[24][better source needed] US 76 Temporary was established on September 1, 1975, to link the newly constructed US 74 and US 76 freeway bypassing Chadbourn and the US 74 and US 76 alignment through Whiteville.