There have been three baronetcies, all in the Baronetage of England, created for members of the Spencer family, both for descendants of two younger sons of Sir John Spencer (1524–1586) of Althorp, Northamptonshire.
The baronetcy was extinct on the death of the seventh Baronet as a minor in 1741.
His sister Alice, who married Sir John Jennings of Sandridge, had 22 children, and was the grandmother of Sarah, 1st Duchess of Marlborough and of her cousin and political rival Abigail Masham.
He died without male issue in 1633 and the Baronetcy was extinct, but was recreated on 26 September 1642 for his brother and heir Brocket Spencer.
His estate was inherited by his four daughters, and ultimately by his great-granddaughter who married Sir Thomas Salusbury