Fisher was introduced to martial arts, when he began practicing Shotokan Karate and Jeet Kun Do at a young age in his school's cafeteria.

Fisher made his professional mixed martial arts debut in 2002 and compiled a record of 14–1 before being signed by the UFC.

He made his UFC debut at Ultimate Fight Night 2, scoring a second-round submission victory over Thiago Alves.

When Stout's original opponent Kenny Florian sustained an injury in training that left him unable to compete, Fisher took the fight on very late notice, reportedly having to cut twenty pounds in the final two days leading up to the match.

In a highly anticipated rematch, Fisher defeated Sam Stout at Fight Night 10 by unanimous decision after three rounds.

[8] With his shoulder healed, Fisher was next scheduled to fight young up and comer Jeremy Stephens at The Ultimate Fighter: Team Rampage vs.

Fisher defeated Shannon Gugerty by submission due to a triangle choke at UFC 90 in Chicago on October 25, 2008.

[18] Fisher decided against retirement and was expected to face Yves Edwards on July 27, 2013 at UFC on Fox 8.

[20] It was later revealed that Fisher was suffering from chronic traumatic encephalopathy, which was likely a direct result of multiple concussive head injuries sustained from his career as a mixed martial artist.

[21] Neurological doctors examining Fisher identified that he was unable to hop on one foot, and was incapable of tandem walking.

He and his family considered taking legal action against the UFC on the basis that his injuries were likely a direct result of his career with the organization, but elected not to do so.

[24] Fisher owns and operates Glory Martial Arts Fitness, a gym in Sylva, North Carolina.