Infestation by these trematodes leads to the disease spirorchiidiosis.

[1][2] It has been synonymised with Proparorchiidae Ward, 1921, Spirorchidae Stunkard, 1921, and Spirorchiidae MacCallum, 1921.

[3][4] Marine species have been reported to infect vermetid gastropods belonging to the genera Thylacodes, Thylaeodus, and Dendropoma, and terebellid polychaetes belonging to the genera Amphitrite and Enoplobranchus as intermediate hosts.

[5][3][6] The cardiovascular parasites Learedius learedi, Hapalotrema postorchis, Monticellius indicum and Amphiorchis solus have been found in the green sea turtle (Chelonia mydas).

[7] Spirhapalum siamensis is a parasite found in the heart of the Amboina box turtle (Cuora amboinensis).