Spitfire Ace is a combat flight simulator video game created and published by MicroProse in 1982 shortly after it was founded.

It was one of the first video games designed and programmed by Sid Meier, originally developed for Atari 8-bit computers and ported to the Commodore 64 and IBM PC compatibles (as a self-booting disk) in 1984.

The game puts the player in the pilot's seat during World War II.

In his 2020 memoir, Meier described Spitfire Ace as "the kind of game we'd probably call an expansion pack today.

It used the same code base as Hellcat Ace, but moved the battle scenarios from the Pacific to the European theater.