The Split Channel (Croatian: Splitski kanal), is a channel in the Adriatic Sea, off the coast of mainland Dalmatia, defined by the southern shores of the island of Čiovo, the northern shores of the island of Šolta and the western shores of the island of Brač.

It is accessible from the open sea through the Drvenik Channel or Šolta Channel from the west, and through the Split Gates (Splitska vrata) straits—narrow passage between Šolta and Brač to the south of the Split Channel.

All the access routes accommodate capesize ships.

In the Split Gates lies Mrduja island, an islet notable for being the turning point of the local Mrduja Regatta, an annual sailboat competition.

On the Šolta side of the channel, there are no villages in the immediate vicinity.