Two other pictures bore this same title, one released in 1916 by Fox and another by MGM in Sporting Blood (1940).

Gambler Rid Riddell (Clark Gable) works for Tip Scanlon (Lew Cody), a crooked gambler, who buys Tommy-Boy, a racehorse from a wealthy man (Hallam Cooley) whose spoiled wife (Marie Prevost) loses interest.

Tip and Rid consistently win with the horse in both honestly and dishonestly run races.

But before long, Tommy Boy loses a race he wasn't supposed to, and the mob is after Tip.

Tip is murdered but not before giving Tommy Boy to his girlfriend (Madge Evans) who sets out to rehabilitate herself and the horse.