Sprague River is an unincorporated community in Klamath County, Oregon, United States.

The community is about 45 miles (72 km) northeast of Klamath Falls near the Sprague River, northwest of Oregon Route 140.

[5] Sprague River post office, named after the stream, was established September 14, 1923, with Benjamin E. Wolford as the first postmaster.

[5] There was an earlier post office named Sprague River farther east and upstream of the current community, at the site of the current town of Bly, Oregon[5] Sprague River had a station on the Oregon, California and Eastern Railway,[5] which by 1927 reached from Klamath Falls to Bly.

[7] After 1990, the rail line near Sprague River became part of a rail trail, the OC&E Woods Line State Trail, managed by the Oregon Parks and Recreation Department.