The Spring Hill College Quadrangle is a grouping of historic structures on the campus of Spring Hill College in Mobile, Alabama, United States.

The original main building was constructed in 1831 in the Greek Revival style, but burned in 1869.

It was replaced within the year by a new main building on the same site in a Neo-Renaissance style.

The perimeter of the quadrangle is enclosed by an open arched arcade, topped by crenellation.

This article about a property in Alabama on the National Register of Historic Places is a stub.