The park is located to the south of Bloomington, about 3 miles (5 km) east of the city of Mitchell on Indiana Highway 60.

It contains a settler's village, the Gus Grissom Memorial (with the accompanying Gemini 3 space capsule), a nature center, and campgrounds.

The Mitchell Karst Plain Nature Preserve is notable for its large number of sinkholes, more than 1000 per square mile.

Also of interest is a memorial to Mitchell, Indiana-native, Gus Grissom, one of the original Mercury Seven astronauts, who died in the Apollo 1 accident.

The campground features 188 Class A campsites which include 30 amp electric service, a fire ring, and a picnic table for each site.