Springer Publishing's first landmark publications included Livestock Health Encyclopedia by R. Seiden and the 1952 Handbook of Cardiology for Nurses.

Nursing publications grew rapidly in number, as Modell's Drugs in Current Use, a small annual paperback, sold over 150,000 copies over several editions.

Solomon Garb's Laboratory Tests for Nurses, first published in 1954, sold nearly 240,000 copies over six editions in 25 years.

Gerontology was a growing topic of interest, and in the 1960s Bernhard Springer published six titles on aging.

After Bernhard Springer's death in 1970,[2] his wife Ursula assumed responsibility for the company, and the firm continued to expand, adding titles in social work, counseling, rehabilitation, and public health, in addition to publishing journals, and annual reviews.