Springfield Catholic High School is a parochial, Roman Catholic high school in Springfield, Missouri, United States.

It is located in the Roman Catholic Diocese of Springfield-Cape Girardeau.

Springfield Catholic High School was established in 1916 as St. Agnes High School to serve the families of St. Agnes Parish.

The school was renamed Springfield Catholic in 1974 and relocated to its present location in 1986.

Generous donations gathered by funding campaigns helped to replace facilities and remodel a portion of the school.