[1][2] The series follows master spy Twilight, who must disguise himself as psychiatrist Loid Forger and build a mock family in order to investigate political leader Donovan Desmond.

[5] For the first part of the season: the first opening theme is directed by Masashi Ishihama and uses the song "Mixed Nuts" (ミックスナッツ, Mikkusu Natsu) performed by Official Hige Dandism.

The first ending theme is directed by Atsushi Nishigori and uses the song "Comedy" (喜劇, Kigeki) performed by Gen Hoshino.

[6][7][8][9][10] For the second part of the season: the second opening theme is directed by Tetsurō Araki and uses the song "Souvenir" performed by Bump of Chicken.

To satisfy her demands, Loid uses WISE's resources to rent a castle and drafts his fellow agents in her reenactment games.

"Fullmetal Lady": Sylvia's daily life as a spy is shown as she evades the SSS to meet with Twilight and discuss Operation Strix.

However, that night, George learns that his family's company is, in fact, not being shut down, and thus, he has to return to school the next day, greatly embarrassed.

"Investigate the General Hospital": For a school report on a career she is interested in, Anya accompanies Loid to learn about his cover job as a psychiatrist.