On March 6, 2007, Spyker announced the C12 Zagato at the Salon International de l'Auto in Geneva.

The C12 Zagato featured all-new design elements inspired by Formula One.

The C12 Zagato was to be offered with a choice of a 6-speed automatic gearbox with paddle-shifters or a traditional 6-speed manual.

However, in July 2007, it was announced that C12 production was delayed, and a couple of months later in October announced that it was cancelled, as Spyker had decided to focus their resources on other models such as the C8 and the then-upcoming D8.

The C12 Zagato develops 493 hp (500 PS; 368 kW) and 610 N⋅m (450 lb⋅ft) from the specially-tuned W12 engine.