The group originally consisted of Southern rappers Lil Wayne, Gudda Gudda, Kidd Kidd, T-Streets, Raw Dizzy, Young Yo, Sha Tura, Fee Banks, and Supa Blanco, with Raj Smoove as the in-house producer.
In 2004, Sqad Up released their debut album Now or Never on their independent label Money Yung'N Records.
In the late 1990s, Lil Wayne met Young Yo in high school and they became close friends, sparked by a shared interest in hip hop culture and fashion.
When Juvenile came on board and they got the Cash Money and Universal deal Wayne had to go on the road and he asked me to go on tour with him", says Yo.
Yo realized the opportunity in front of him and decided to call his brother Supa Blanco to invite him on tour as well.
That same year, Sqad Up went on a number of tours to support their sophomore album We Here Now, but it was never released and the group disbanded.