This district is named after Indian Guru Sri Sathya Sai Baba, who contributed to improving the infrastructure of the Rayalaseema region by building schools, university, free healthcare institutions and drinking water projects.

[6] Mallappakonda, Penukonda , Madakasira and Nagasamudram are the major hill ranges, which account for the uncultivable, uninhabitable regions in the district.

[10] Gold, diamond, quartz, granite, pyrophyllite, road metal, gravel are found in the district.

[14] The district is divided into 4 revenue divisions: Dharmavaram, Kadiri, Penukonda and Puttaparthi, which are further subdivided into a total of 32 mandals, each headed by a sub-collector.

The district has three municipalities at Hindupur, Dharmavaram, Kadiri and three Nagar Panchayats at Puttaparthi, Penukonda and Madakasira.

Kia India Private Limited manufactures automobiles in 536-acre factory in Yerramanchi village of Penukonda mandal.

Texport Industries located at Gollapuram in Hindupur mandal manufactures woven and knitted apparel fabric.

[18] Sri Sathya Sai Institute of Higher Learning (SSSIHL), a deemed university with headquarters at Puttaparthi and additional campuses at Anantapur, kadugodi and Muddenahalli in Karnataka provides free education to students, in various courses has completed 40 years of service in 2021.

[22] Sathya Sai Baba, 20th century Indian guru with worldwide devotees was born in Puttaparthi.

He contributed to improving the infrastructure of the Rayalaseema region by building schools, university, free healthcare institutions and drinking water projects.