Srikanth had an elder brother who died due to dengue after he returned from United States.

[11] Srikanth was selected to play the lead role in Kathir's Kadhal Virus (2002) and spent a year preparing for the film, before being replaced by fellow newcomer Richard.

[11] Further potential projects directed by Bharathiraja and K. Balachander also did not work out, before he was cast by Sasi in Roja Kootam (2002), after the original lead actor had opted out.

He won the Tamil Nadu State Film Award Special Prize for his role in Parthiban Kanavu (2003), directed by Karu Pazhaniappan.

Kana Kandaen (2005) directed by K. V. Anand, with the Malayalam actor Prithviraj in his first Tamil role.

"[18] TSV Hari at Rediff.com responded negatively to Kizhakku Kadarkarai Salai, noting a thin script and "meaningless songs".

[19] This was the third film and last collaboration between the director S. S. Stanley and Srikanth after April Maadhathil and Mercury Pookkal.

In 2012, he was first seen in S. Shankar's comedy-drama Nanban, which featured him as part of an all-star cast including Vijay, Jiiva, Ileana D'Cruz and Sathyaraj.

Later, he acted in Buddy (2013) and Kathai Thiraikathai Vasanam Iyakkam (2014) as guest appearance directed by R. Parthiepan.

In 2019, his next film was Rocky: The Revenge, a Tamil action crime thriller centered on dogs.

[27] Srikanth plays serial killer in the action thriller Mirugaa (2021), followed by three Telugu films Y (2021), Asalem Jarigindi (2021) and 10th Class Diaries (2022).