Prior to his political and media career, Gendron practised law and taught at the CEGEP level.

Gendron first gained media attention by enacting a municipal curfew forcing minors to stay off the street after 10 p.m. in Huntingdon, in an attempt to reduce juvenile crime.

In 2005, he claimed that Quebec premier Jean Charest was a "murderer" ("meurtrier") for his government's initial refusal to subsidize Herceptin, a new drug against breast cancer;[3] he later apologized for these comments after being served legal papers.

[5] In December 2011, Gendron was criticized for a broadcast of his show Face à Face in which he stated that “Products made in Israel on land stolen from the Palestinians that is walled in, in an apartheid regime where they are cut off, it’s very serious.... And a country like that does not deserve to exist.” The remarks sparked outrage from Jewish groups after a clip of the show was posted on YouTube by HonestReporting Canada, a website that monitors the media for anti-Israel bias.

The California-based Simon Wiesenthal Center has since launched a protest against the network demanding Mr. Gendron's show be cancelled.

Israel as it is today is not my cup of tea.”[6] On January 12, 2009, Stéphane Gendron insulted Canadian Prime Minister Stephen Harper in a letter that he also posted on his blog.

You are just a band-wagon follower of Israel, its racist Government, and the dumb president Bush and the Republican Party; Go and read some history books.

Tonya Welburn lost her seat during the general election of November 2009, as well as her father who was also a councillor but running for mayor.

[10] His comments were denounced by the Society for the Prevention of Cruelty to Animals, and a petition was launched that demanded he be investigated.

[15] Following the ADQ's disappointing results in the 2008 election, Gendron expressed an interest in running for the party leadership in the event of Dumont's resignation.