[2] Fowler bought a home in the riverside village of Mount Pleasant, where planters from Christ Church Parish would vacation in the summer to avoid malarial conditions inland.

In 1857 and 1858, the congregation built a Carpenter Gothic sanctuary to a design by Charleston architect Edward Brickell White.

[3] The chapel was closed during the Civil War when Union shelling forced many residents of Mount Pleasant to evacuate Upstate.

St. Andrew's continued as a chapel of ease until 1954, when—with the growth of Mount Pleasant as a Charleston suburb in the mid-20th century due to the Cooper River Bridge—the congregation received parish status.

[7] In 2010, St. Andrew's members voted overwhelmingly to disaffiliate from the Episcopal Diocese of South Carolina and join the newly formed Anglican Church in North America.

[7] An electrical fire in April 2018 resulted in the complete destruction of the 1996 ministry center, although the historic church was unharmed.

The new center's architecture reflects the Carpenter Gothic design, and its furnishings include the chancel cross, communion table and baptismal font that survived the fire.

[15] St. Andrew's partners with Christian counseling organizations to refer parishioners needing professional mental health care.

It offers courses in conjunction with Gordon Conwell Theological Seminary as well as an Anglican studies certificate for ordinands.