Built in 1853, it is a locally distinctive example of Carpenter Gothic architecture, and is the only known statewide work of architect James Renwick Jr.

[2] St. Anne's is located in central Calais, at the northern corner of Church and Washington Streets.

It is a single-story wood-frame structure, with a gable roof, board-and-batten siding, and a granite foundation.

The right tower houses the main entrance on the first level, a narrow lancet window on the second, the main belfry with louvered lancet openings on the third, and a large clock on the fourth; it is topped by a low jigsawn balustrade with corner pinnacles.

The main gable, which has a stepped front, has a four-part stained-glass window with tracery at its center.